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Related party transactions (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 6 Months Ended
Nov. 08, 2018
Nov. 05, 2018
Oct. 26, 2017
Jun. 30, 2017
Jun. 26, 2017
Feb. 17, 2017
May 31, 2019
Feb. 28, 2017
Jun. 30, 2019
Stock transaction disclosures                  
Net proceeds from issuance of stock                 $ 11
Minimum | Common Stock                  
Stock transaction disclosures                  
Proceeds from issuance of common stock   $ 4,500              
Underwritten Public Offering | Common Stock                  
Stock transaction disclosures                  
Issuance of common stock, net of issuance costs (in shares) 19,999,999     4,800,000       5,750,000  
Public offering price (in dollars per share) $ 2.30     $ 6.25       $ 5.00  
Proceeds from issuance of common stock       $ 30,000          
Payments of stock issuance costs       $ 200          
Term of option to purchase share       30 days          
Shares offered to underwriters under option granted (in shares)       720,000          
Net proceeds from issuance of stock $ 43,400       $ 34,300 $ 26,700      
Underwritten Public Offering | Minimum | Common Stock                  
Stock transaction disclosures                  
Proceeds from issuance of common stock   30,000              
Over-allotment option | Common Stock                  
Stock transaction disclosures                  
Issuance of common stock, net of issuance costs (in shares) 2,608,695         750,000      
Senior Secured Credit Facility | Conversion Of Convertible Notes                  
Stock transaction disclosures                  
Number of shares issued upon conversion of debt     929,967            
Amount of debt converted into stock     $ 6,600            
Conversion price     $ 7.08            
Conversion price, expressed as a percentage of stock price     95.00%            
Number of trading days used to determine conversion stock price     3 days            
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019                  
Stock transaction disclosures                  
Payment of facility   $ 7,500         $ 7,500    
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019 | Common Stock                  
Stock transaction disclosures                  
Number of trading days used to determine conversion stock price   10 days              
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2019 | Maximum | Common Stock                  
Stock transaction disclosures                  
Number of shares issued upon conversion of debt   2,135,625              
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020                  
Stock transaction disclosures                  
Principal repayment to be paid   $ 15,000              
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Common Stock                  
Stock transaction disclosures                  
Conversion price   $ 10.00              
Conversion price, expressed as a percentage of stock price   95.00%              
Number of trading days used to determine conversion stock price   3 days              
Debt issued to entities affiliated with Deerfield | Second Amendment Facility Due in May 2020 | Maximum | Common Stock                  
Stock transaction disclosures                  
Number of shares issued upon conversion of debt   3,796,668              
Conversion price, expressed as a percentage of stock price   83.00%              
Investor | Debt issued to entities affiliated with Deerfield | Senior Secured Credit Facility                  
Related party transactions                  
Face amount of debt at time of related party stock purchase               $ 60,000