Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The total charge for the use of long-lived depreciable assets subject to a lease meeting the criteria for capitalization.

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The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Property and equipment (Details) - USD ($)	3 Months Ended	12 Months Ended
Property and equipment (Details) - USD ($)	Dec. 31, 2016	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Property and equipment
Property and equipment gross		$ 16,840,000	$ 15,429,000
Accumulated depreciation and amortization (including $633 and $157 at December 31, 2018 and 2017, respectively, applicable to capital leases)		(8,926,000)	(7,226,000)
Property and equipment, net		7,914,000	8,203,000
Depreciation and amortization expense		1,750,000	1,363,000	$ 1,598,000
Accumulated depreciation and amortization of capital lease		633,000	157,000
Net proceeds of depreciated equipment				$ 415,000
Assets under capital lease
Property and equipment
Property and equipment gross		3,327,000	3,222,000
Leasehold improvements
Property and equipment
Property and equipment gross		4,340,000	4,195,000
Manufacturing, packaging and lab equipment
Property and equipment
Property and equipment gross		6,821,000	5,300,000
Office furniture and equipment
Property and equipment
Property and equipment gross		2,164,000	1,656,000
Assets under construction
Property and equipment
Property and equipment gross		$ 188,000	$ 1,056,000
Equipment
Property and equipment
Net proceeds of depreciated equipment	$ 415,000