Organization and Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2016

Property Plant And Equipment Estimated Useful Lives

Property and equipment are recorded at cost and depreciated using the straight line method over their estimated useful lives as follows:

Computer equipment		3 years
Office equipment		3 years
Furniture and fixtures		5 years
Laboratory equipment		7 years
Building asset under facility lease		25 years

Summary of Assumptions Used in Determining the Fair Value of Preferred Stock Warrants

For the year ended December 31, 2014, inputs used in the Black-Scholes model are presented below.

	Year Ended December 31, 2014
Estimated dividend yield	0.00%
Expected volatility	75.86% - 100%
Risk-free interest rate	0.02% - 0.13%
Expected term (years)	0.17 to 0.92
Fair value of preferred stock	$6.00 to $13.71
Exercise price	$	6.00

Summary of Changes in the Preferred Stock Warrant Liability Using Significant Unobservable Inputs (Level 3)

The changes in the balances of Level 3 liabilities for the year ended December 31, 2014 were as follows:

Fair Value Measurements Using Significant Unobservable Inputs (Level 3)

Beginning

Balance

Revaluations

Included In

Earnings

Exercises

Expirations

Ending

Balance

Warrant liability—December 31, 2014

271

641

(854

)

(58

)

—

Summary of Anti-dilutive Securities Excluded from Calculation of Weighted Average Common Shares Outstanding

The following securities, presented on a common stock equivalent basis, have been excluded from the calculation of weighted average common shares outstanding for the years ended December 31, 2016, 2015 and 2014 because the effect is anti-dilutive due to the net loss reported in each of those periods. All share amounts presented in the table below represent the total number outstanding as of the end of each period. The convertible preferred stock securities will no longer be potentially dilutive in future periods because, as discussed above, in September 2016, upon completion of the IPO, all outstanding shares of the convertible preferred stock were converted into shares of common stock at their conversion prices.

	December 31,
	2016		2015		2014
Convertible preferred stock		—		8,776,269		5,658,942
Stock options outstanding		825,130		458,234		336,513