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Licensing and Collaboration Arrangements (Details)
3 Months Ended 9 Months Ended
Jan. 01, 2022
USD ($)
Nov. 07, 2021
Feb. 21, 2020
USD ($)
Oct. 05, 2018
USD ($)
Sep. 28, 2018
USD ($)
Oct. 13, 2017
USD ($)
Jan. 12, 2017
USD ($)
Dec. 29, 2015
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2021
agreement
Dec. 30, 2015
Jun. 27, 2012
USD ($)
Collaborative Arrangements Transactions [Line Items]                              
Amount at which royalty payments are due         $ 20,833,000                    
Maximum royalty payment         $ 6,500,000                    
Milestone and royalty payments                 $ 0 $ 0 $ 0 $ 0      
KNOW Bio                              
Collaborative Arrangements Transactions [Line Items]                              
Written notice to terminate, period                     90 days        
Percentage of outstanding member interests of KNOW Bio distributed to stockholders                           100.00%  
Exclusive option term for development and commercialization               3 years              
Upfront license agreement payment due upon execution           $ 250,000                  
Licensing Agreements                              
Collaborative Arrangements Transactions [Line Items]                              
Accrual for future payments                 $ 0   $ 0        
UNC License Agreement                              
Collaborative Arrangements Transactions [Line Items]                              
Potential regulatory and commercial milestones payable under agreement                             $ 425,000
Amended Sato Agreement                              
Collaborative Arrangements Transactions [Line Items]                              
License agreement additional term                     2 years        
Maximum preclinical studies amount             $ 1,000,000                
Written notice to terminate, period             120 days                
Written notice to terminate due to material breach, term             60 days                
Upfront fee refundable in event of termination       $ 0                      
MC2 Agreement                              
Collaborative Arrangements Transactions [Line Items]                              
Term of arrangement 7 years                            
MC2 Agreement | Royalty Payment, Mid-Teens Percentage                              
Collaborative Arrangements Transactions [Line Items]                              
Amount at which royalty payments are due $ 65,000,000                            
MC2 Agreement | Royalty Payment, Upper Single Digits Percentage                              
Collaborative Arrangements Transactions [Line Items]                              
Amount at which royalty payments are due 105,000,000                            
MC2 Agreement | Incentive Fee                              
Collaborative Arrangements Transactions [Line Items]                              
Amount at which royalty payments are due $ 30,000,000                            
Incentive fee percentage 5.00%                            
Maximum incentive fee $ 1,500,000                            
Aspect Agreement and Rhofade Acquisition Agreement                              
Collaborative Arrangements Transactions [Line Items]                              
Royalty percentage due                         25.00%    
Abbreviated New Drug Application (ANDA) Settlement Agreements                              
Collaborative Arrangements Transactions [Line Items]                              
Number of settlement agreements (in agreements) | agreement                         2    
Cloderm Agreement                              
Collaborative Arrangements Transactions [Line Items]                              
Initial term of agreement         5 years                    
Renewal term of agreement         1 year                    
Termination notice period         9 months                    
OTC License Agreement                              
Collaborative Arrangements Transactions [Line Items]                              
Termination period without notice     9 months                        
Term of arrangement     10 years                        
OTC License Agreement | Regulatory Milestones                              
Collaborative Arrangements Transactions [Line Items]                              
Maximum royalty payment     $ 9,500,000                        
OTC License Agreement | Commercial Milestones                              
Collaborative Arrangements Transactions [Line Items]                              
Maximum royalty payment     $ 20,000,000                        
OTC License Agreement | Minimum                              
Collaborative Arrangements Transactions [Line Items]                              
Royalty percentage due     32.00%                        
Termination notice period     60 days                        
OTC License Agreement | Maximum                              
Collaborative Arrangements Transactions [Line Items]                              
Royalty percentage due     50.00%                        
Termination notice period     3 months                        
Nuvail Agreements                              
Collaborative Arrangements Transactions [Line Items]                              
Renewal term of agreement   5 years                          
Termination notice period   12 months                          
Gross sales period by which termination fee is determined   12 months