Stockholders' Equity - Schedule of Outstanding Warrants to Purchase Common Stock (Details) - $ / shares	Sep. 30, 2022	Jun. 09, 2022	Dec. 31, 2021	Mar. 26, 2020	Mar. 03, 2020
Warrants to purchase common stock
Class of Stock [Line Items]
Warrants owned (in shares)	5,535,637		1,274,176
Common Warrant
Class of Stock [Line Items]
Warrant exercise price (in USD per share)					$ 3.00
Common Warrant | June 2022 Registered Direct Offering
Class of Stock [Line Items]
Warrant exercise price (in USD per share)		$ 2.851
Common Warrant | Warrants to purchase common stock | January 2018 Public Offering
Class of Stock [Line Items]
Warrants owned (in shares)	0		999,850
Warrant exercise price (in USD per share)	$ 46.60		$ 46.60
Common Warrant | Warrants to purchase common stock | June 2022 Registered Direct Offering
Class of Stock [Line Items]
Warrants owned (in shares)	5,261,311		0
Warrant exercise price (in USD per share)	$ 2.851	$ 2.851
Common Warrant | Warrants to purchase common stock | March 2020 Public Offering
Class of Stock [Line Items]
Warrants owned (in shares)	252,417		252,417
Warrant exercise price (in USD per share)	$ 3.00		$ 3.00
Underwriter Warrant
Class of Stock [Line Items]
Warrant exercise price (in USD per share)					$ 3.75
Underwriter Warrant | Warrants to purchase common stock | March 2020 Registered Direct Offering
Class of Stock [Line Items]
Warrants owned (in shares)	11,304		11,304
Warrant exercise price (in USD per share)	$ 3.75		$ 3.75
Placement Agent Warrant
Class of Stock [Line Items]
Warrant exercise price (in USD per share)				$ 5.375
Placement Agent Warrant | Warrants to purchase common stock | March 2020 Registered Direct Offering
Class of Stock [Line Items]
Warrants owned (in shares)	10,605		10,605
Warrant exercise price (in USD per share)	$ 5.375		$ 5.375