Organization and Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2019

Property and equipment are recorded at cost and depreciated using the straight-line method over their estimated useful lives as follows:



Computer and office equipment	3 years
Furniture and fixtures	5-7 years
Laboratory equipment	7 years
Building asset under facility lease	25 years

Property and equipment consisted of the following:



	December 31,
	2019			2018
Computer equipment	$	575		$	577
Furniture and fixtures	305			312
Laboratory equipment	7,898			7,442
Office equipment	339			400
Building related to facility lease obligation	—			10,557
Leasehold improvements	7,068			1,168
Property and equipment, gross	16,185			20,456
Less: Accumulated depreciation and amortization	(5,679		)	(4,588		)
Total property and equipment, net	$	10,506		$	15,868

Summary of Anti-dilutive Securities Excluded from Calculation of Weighted Average Common Shares Outstanding

The following securities, presented on a common stock equivalent basis, have been excluded from the calculation of weighted average common shares outstanding for the years ended December 31, 2019 and 2018 because the effect is anti-dilutive due to the net loss reported in each of those periods. All share amounts presented in the table below represent the total number outstanding as of the end of each period.



	December 31,
	2019	2018
Warrants to purchase common stock associated with January 2018 public offering (Note 10)	10,000,000	10,000,000
Stock options outstanding under the 2008 and 2016 Plans (Note 11)	1,663,803	1,671,666
Stock appreciation rights outstanding under the 2016 Plan (Note 11)	1,000,000	—
Inducement options outstanding (Note 11)	125,500	100,500