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Related Party Transactions (Details)
$ in Thousands
12 Months Ended
Dec. 31, 2018
USD ($)
director
shares
Dec. 31, 2017
USD ($)
shares
Related Party Transaction [Line Items]    
Common stock, number of shares held (in shares) | shares 26,056,735 16,005,408
Research and development expense $ 23,045 $ 25,212
Board Members    
Related Party Transaction [Line Items]    
Common stock, number of shares held (in shares) | shares 782,083 1,585,916
Malin    
Related Party Transaction [Line Items]    
Number of directors also affiliated with related party during year | director 2  
Malin | General and administrative    
Related Party Transaction [Line Items]    
Recognized out-of-pocket travel expenses   $ 230
Malin | Novan, Inc    
Related Party Transaction [Line Items]    
Beneficial ownership percentage 10.00%  
Cilatus BioPharma AG    
Related Party Transaction [Line Items]    
Research and development expense $ 601 $ 69
Estimated fees remaining $ 230