Segment Information - Reportable segments (Details) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Segment Reporting Information [Line Items]
Product revenue	$ 32,143		$ 36,820		$ 66,390	$ 74,873
Product revenue - extensible list	Product		Product		Product	Product
Operating expenses:
Research and development	$ 36,426		$ 45,759		$ 78,676	$ 98,564
Selling, general and administrative	32,590		32,918		61,803	62,859
Acquired in-process research and development			2,204			2,204
Other operating expenses	13,293		3,884		17,023	7,591
Total expenses	91,524		94,402		176,130	190,466
Operating loss	(59,381)		(57,582)		(109,740)	(115,593)
Other income (expense):
Interest expense	(9,674)		(8,770)		(18,774)	(16,807)
Foreign currency loss	(2,489)		(206)		(3,468)	(752)
Other income	171		107		320	290
Other income (expense), net	(11,992)		(8,869)		(21,922)	(17,269)
Loss before income taxes	(71,373)		(66,451)		(131,662)	(132,862)
Income tax benefit	41		3		162	137
Net loss	(71,332)	$ (60,169)	(66,448)	$ (66,277)	(131,500)	(132,725)
Product
Operating expenses:
Cost of sales	7,872		8,294		15,942	16,562
Intangible asset amortization
Operating expenses:
Cost of sales	1,343		1,343		2,686	2,686
U.S.
Segment Reporting Information [Line Items]
Product revenue	$ 22,736		$ 27,680		$ 47,244	$ 59,381
Product revenue - extensible list	Product		Product		Product	Product
Operating expenses:
Research and development	$ 34,409		$ 43,774		$ 74,874	$ 94,604
Selling, general and administrative	26,574		26,351		50,493	50,672
Acquired in-process research and development			2,204			2,204
Other operating expenses	13,293		3,884		17,023	7,591
Total expenses	79,357		82,235		152,926	167,872
Operating loss	(56,621)		(54,555)		(105,682)	(108,491)
U.S. | Product
Operating expenses:
Cost of sales	4,461		5,402		9,295	11,560
U.S. | Intangible asset amortization
Operating expenses:
Cost of sales	620		620		1,241	1,241
ex U.S.
Segment Reporting Information [Line Items]
Product revenue	$ 9,407		$ 9,140		$ 19,146	$ 15,492
Product revenue - extensible list	Product		Product		Product	Product
Operating expenses:
Research and development	$ 2,017		$ 1,985		$ 3,802	$ 3,960
Selling, general and administrative	6,016		6,567		11,310	12,187
Total expenses	12,167		12,167		23,204	22,594
Operating loss	(2,760)		(3,027)		(4,058)	(7,102)
ex U.S. | Product
Operating expenses:
Cost of sales	3,411		2,892		6,647	5,002
ex U.S. | Intangible asset amortization
Operating expenses:
Cost of sales	$ 723		$ 723		$ 1,445	$ 1,445