Share-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Share-Based Compensation

Share-Based Compensation Expense Recognized in Accompanying Statements of Operations

Share-based compensation expense for all equity-based programs, including stock options, restricted stock units and the employee stock purchase plan, for the three and six months ended June 30, 2022 and 2021 was recognized in the accompanying Consolidated Statements of Operations and Comprehensive Loss as follows (in thousands):

	Three months ended June 30,				Six months ended June 30,
	2022		2021		2022		2021
Research and development	$	2,505	$	3,474	$	5,734	$	6,350
Selling, general and administrative		2,897		3,888		6,300		5,051
Total share-based compensation expense	$	5,402	$	7,362	$	12,034	$	11,401

Summary of Stock Options Activity

				Weighted
		Weighted		Average	Aggregate
		Average		Remaining	Intrinsic
	Number of	Exercise		Contractual	Value
	Options	Price		Term (Years)	(Thousands)
Outstanding at December 31, 2021	7,010,039	$	33.36
Granted	539,250		1.95
Exercised	—		—
Forfeited	(470,499)		25.96
Outstanding at June 30, 2022	7,078,790	$	31.46	5.5	$	9
Vested and expected to vest at June 30, 2022	6,893,081	$	32.20	5.4	$	6
Vested and exercisable at June 30, 2022	5,771,285	$	37.33	4.7	$	—

Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award

The following table summarizes information about our stock options as of and for the three and six months ended June 30, 2022 and 2021 (in thousands, except per share amounts):

	Three months ended June 30,				Six months ended June 30,
	2022		2021		2022		2021
Weighted-average grant date fair value per share	$	1.38	$	4.72	$	1.47	$	4.85
Intrinsic value of options exercised	$	—	$	1	$	—	$	15
Cash received from stock option exercises	$	—	$	8	$	—	$	35

Summary of activity related to our unvested RSUs

		Weighted
		Average
	Number of	Grant Date
	Units	Fair Value
Unvested at December 31, 2021	3,683,422	$	8.36
Granted	2,762,399		1.95
Vested	(1,236,352)		8.90
Forfeited	(255,354)		5.12
Unvested at June 30, 2022	4,954,115	$	4.82
Expected to vest after June 30, 2022	4,185,482	$	5.08