CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 94,579	$ 143,428
Accounts receivable, net	18,569	26,868
Inventories, net	13,232	13,688
Prepaid research and development expenses	4,734	2,397
Other current assets	11,170	11,706
Total current assets	142,284	198,087
Inventories	94,082	109,848
Property and equipment, net	5,386	6,554
Right-of-use assets, net	17,761	19,109
Intangible assets, net	57,686	60,371
Goodwill	63,074	63,074
Other assets	12,583	15,790
Total assets	392,856	472,833
Current liabilities:
Accounts payable	24,228	27,308
Accrued research and development expenses	25,988	35,121
Lease liabilities	3,605	3,414
Borrowings under financing agreement	25,500	8,500
Other accrued expenses	41,951	50,871
Total current liabilities	121,272	125,214
Long-term lease liabilities - less current portion	17,895	19,731
Convertible senior notes	437,800	436,772
Borrowings under financing agreement - less current portion	183,584	169,956
Total liabilities	760,551	751,673
Commitments and contingencies (Note 14)
Stockholders' equity:
Preferred stock, par value $0.001 per share; 10,000,000 shares authorized, no shares issued and outstanding at June 30, 2022 and December 31, 2021
Common stock, $0.001 par value per share, 200,000,000 shares authorized at June 30, 2022 and December 31, 2021, respectively; 144,472,733 and 129,109,543 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively	144	129
Additional paid-in capital	2,682,750	2,641,712
Accumulated other comprehensive loss	(41,837)	(43,430)
Accumulated deficit	(3,008,752)	(2,877,251)
Total stockholders' deficit	(367,695)	(278,840)
Total liabilities and stockholders' deficit	$ 392,856	$ 472,833