CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Product revenue	$ 32,143	$ 36,820	$ 66,390	$ 74,873
Product revenue - extensible list	Product	Product	Product	Product
Operating expenses:
Research and development	$ 36,426	$ 45,759	$ 78,676	$ 98,564
Selling, general and administrative	32,590	32,918	61,803	62,859
Acquired in-process research and development		2,204		2,204
Other operating expenses	13,293	3,884	17,023	7,591
Total expenses	91,524	94,402	176,130	190,466
Operating loss	(59,381)	(57,582)	(109,740)	(115,593)
Other income (expense):
Interest expense	(9,674)	(8,770)	(18,774)	(16,807)
Foreign currency loss	(2,489)	(206)	(3,468)	(752)
Other income	171	107	320	290
Other income (expense), net	(11,992)	(8,869)	(21,922)	(17,269)
Loss before income taxes	(71,373)	(66,451)	(131,662)	(132,862)
Income tax benefit	41	3	162	137
Net loss	(71,332)	(66,448)	(131,500)	(132,725)
Other comprehensive income (loss):
Foreign currency translation adjustments, net of tax	1,158	14	1,593	(66)
Other comprehensive income (loss)	1,158	14	1,593	(66)
Comprehensive loss	$ (70,174)	$ (66,434)	$ (129,907)	$ (132,791)
Loss per basic and diluted common share:
Basic net loss per common share	$ (0.50)	$ (0.61)	$ (0.93)	$ (1.25)
Diluted net loss per common share	$ (0.50)	$ (0.61)	$ (0.93)	$ (1.25)
Basic weighted average common shares outstanding	144,036	108,481	141,137	106,375
Diluted weighted average common shares outstanding	144,036	108,481	141,137	106,375
Product
Operating expenses:
Cost of sales	$ 7,872	$ 8,294	$ 15,942	$ 16,562
Intangible asset amortization
Operating expenses:
Cost of sales	$ 1,343	$ 1,343	$ 2,686	$ 2,686