Debt instrument convertible trading days preceding redemption notice maximum.

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Debt instrument interest rate payment day and month.

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Debt Instrument,

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Debt instrument repurchase percentage.

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Represent the maximum amount to be repaid under borrowing agreement.

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Number of countries.

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Number of patients.

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Number of sites.

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Percentage of other amounts received .

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Percentage of royalty payment received

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The ratio of maximum amount required to be repaid to aggregate borrowed amount.

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Represents the maximum cash outflow during the quarterly period from the repayment of aggregate short-term and long-term debt based upon a certain percentage of the revenues generated from the sales and any future out-licensing of Rubraca. Excludes payment of capital lease obligations.

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Represents the maximum cash outflow during the quarterly period from the repayment of aggregate short-term and long-term debt if the label portion of the Rubraca NDA is expanded by the FDA to include such label the treatment of an indication resulting from the ATHENA Trial. Excludes payment of capital lease obligations.

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The remaining balance of debt issuance expenses that were derecognized.

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The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period.

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Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt.

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The price per share of the conversion feature embedded in the debt instrument.

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Ratio applied to the conversion of debt instrument into equity with equity shares divided by debt principal amount.

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Threshold period of specified consecutive trading days within which common stock price to conversion price of convertible debt instrument must exceed threshold percentage for specified number of trading days to trigger conversion feature.

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Minimum percentage of common stock price to conversion price of convertible debt instruments to determine eligibility of conversion.

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Threshold number of specified trading days that common stock price to conversion price of convertible debt instruments must exceed threshold percentage within a specified consecutive trading period to trigger conversion feature.

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Face (par) amount of debt instrument at time of issuance.

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Effective interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium.

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Contractual interest rate for funds borrowed, under the debt agreement.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

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Start date of debt instrument redemption period, in CCYY-MM-DD format.

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Percentage price of original principal amount of debt at which debt can be redeemed by the issuer.

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Fair value amount of debt instrument that was repurchased.

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Period of time between issuance and maturity of debt instrument, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average interest rate of debt outstanding.

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Amount, before accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.

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Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity.

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The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations.

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Long-term Debt (Details) $ / shares in Units, $ in Thousands						1 Months Ended	2 Months Ended	3 Months Ended	6 Months Ended
	May 02, 2022 D	Aug. 13, 2019 USD ($) $ / shares	May 01, 2019 USD ($) country site item	Apr. 16, 2018 USD ($) $ / shares	Sep. 09, 2014 USD ($) D item $ / shares	Apr. 30, 2020 USD ($)	May 31, 2020 USD ($) shares	Jun. 30, 2020 USD ($)	Jun. 30, 2020 USD ($)	Dec. 31, 2019 USD ($)
Debt Instrument
Aggregate principal amount								$ 515,042	$ 515,042
Gain (loss) on extinguishment of debt								(3,277)	(3,277)
2019
Debt Instrument
Repayments of Debt									35,000
2020
Debt Instrument
Repayments of Debt									$ 50,000
Date is prior to Repayment Start Date
Debt Instrument
Debt Instrument Ratio of borrowed amount									1.75%
Date is after Repayment Start Date
Debt Instrument
Debt Instrument Ratio of borrowed amount									2.00%
TPG Sixth Street Partners, LLC
Debt Instrument
Principal amount outstanding								72,500	$ 72,500
Debt issuance costs								1,800	1,800
Unamortized debt issuance costs								$ 1,600	$ 1,600
Number of patients \| item			1,000
Number of countries \| country			25
Effective interest rate								14.50%	14.50%
Debt, Weighted Average Interest Rate			9.75%					10.25%	10.25%
Maximum Amount to be Repaid Under Borrowing Agreement			$ 166,500
Percentage of royalty payment received			19.50%
Percentage of other amounts received			19.50%
Quarterly payments based on a certain percentage of revenues									$ 8,500
Quarterly payments with label portion expanded by FDA									13,500
Aggregate borrowed amount			$ 166,500
Ratio of repayment amount			2
TPG Sixth Street Partners, LLC \| Minimum
Debt Instrument
Number of sites \| site			270
TPG Sixth Street Partners, LLC \| Maximum
Debt Instrument
Aggregate principal amount			$ 175,000
Maximum Amount to be Repaid Under Borrowing Agreement			350,000
Aggregate borrowed amount			$ 350,000
Convertible Senior Unsecured Notes
Debt Instrument
Unamortized debt issuance costs								$ 10,400	$ 10,400	$ 15,400
2021 Notes
Debt Instrument
Convertible senior notes, interest rate					2.50%			2.50%	2.50%
Aggregate principal amount					$ 287,500	$ 32,800		$ 64,418	$ 64,418
Convertible senior notes, maturity date					Sep. 15, 2021				Sep. 15, 2021
Net proceeds from convertible senior notes					$ 278,300
Common stock initial conversion rate per $1,000 in principal amount					16.1616
Convertible senior notes, initial conversion price per share \| $ / shares					$ 61.88
Debt instrument, redemption period start date					Sep. 15, 2018
Last reported sale price of common stock as a percent of conversion price					150.00%
Debt instrument, conversion in effect for number of trading days \| D					20
Debt instrument conversion, consecutive trading day period \| D					30
Debt instrument, trading days preceding redemption notice, maximum \| item					2
Debt instrument redemption price percentage to principal amount					100.00%
Debt instrument repurchase percentage					100.00%
Principal amount outstanding		$ 190,300
Aggregate repurchase price including accrued interest		171,800
Gain (loss) on extinguishment of debt		18,500				(3,300)
Debt issuance costs					$ 9,200
Unamortized debt issuance costs derecognized		$ 2,000
Debt instrument term					7 years
2021 Notes \| Semi Annual Payment, First payment date
Debt Instrument
Interest payment date on senior notes					--03-15
2021 Notes \| Semi Annual Payment, Second payment date
Debt Instrument
Interest payment date on senior notes					--09-15
2024 Notes
Debt Instrument
Convertible senior notes, interest rate		4.50%						4.50%	4.50%
Aggregate principal amount		$ 263,000				$ 36,100	$ 24,300	$ 150,624	$ 150,624
Convertible senior notes, maturity date									Aug. 01, 2024
Net proceeds from convertible senior notes		$ 254,900
Common stock initial conversion rate per $1,000 in principal amount		137.2213					137.2213
Convertible senior notes, initial conversion price per share \| $ / shares		$ 7.29
Debt instrument repurchase percentage		100.00%
Debt issuance costs		$ 8,000
Debt instrument term		5 years
Debt conversion to number of shares of common stock \| shares							3,331,870
2024 Notes \| Semi Annual Payment, First payment date
Debt Instrument
Interest payment date on senior notes		--02-01
2024 Notes \| Semi Annual Payment, Second payment date
Debt Instrument
Interest payment date on senior notes		--08-01
2025 Notes
Debt Instrument
Convertible senior notes, interest rate				1.25%				1.25%	1.25%
Aggregate principal amount				$ 300,000				$ 300,000	$ 300,000
Convertible senior notes, maturity date									May 01, 2025
Net proceeds from convertible senior notes				$ 290,900
Common stock initial conversion rate per $1,000 in principal amount				13.1278
Convertible senior notes, initial conversion price per share \| $ / shares				$ 76.17
Debt instrument repurchase percentage				100.00%
Debt issuance costs				$ 9,100
Debt instrument term				7 years
2025 Notes \| Semi Annual Payment, First payment date
Debt Instrument
Interest payment date on senior notes				--05-01
2025 Notes \| Semi Annual Payment, Second payment date
Debt Instrument
Interest payment date on senior notes				--11-01
Borrowing Exceeds $166.5 million \| TPG Sixth Street Partners, LLC \| Minimum
Debt Instrument
Quarterly payments based on a certain percentage of revenues									$ 8,940
Borrowing Exceeds $166.5 million \| TPG Sixth Street Partners, LLC \| Maximum
Debt Instrument
Quarterly payments with label portion expanded by FDA									$ 14,190
Scenario, Actual \| 2025 Notes
Debt Instrument
Last reported sale price of common stock as a percent of conversion price	150.00%
Debt instrument, conversion in effect for number of trading days \| D	20
Debt instrument conversion, consecutive trading day period \| D	30
Debt instrument, trading days preceding redemption notice, maximum \| D	2
Debt instrument redemption price percentage to principal amount	100.00%