CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenues:
Product revenue	$ 39,887	$ 32,978	$ 82,451	$ 66,096
Product revenue - extensible list	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Operating expenses:
Research and development	$ 69,878	$ 70,746	$ 138,099	$ 132,777
Selling, general and administrative	41,902	48,029	84,500	95,791
Other operating expenses	355		3,805
Total expenses	122,535	126,437	247,112	244,756
Operating loss	(82,648)	(93,459)	(164,661)	(178,660)
Other income (expense):
Interest expense	(6,739)	(3,817)	(16,300)	(7,407)
Foreign currency gain (loss)	142	(226)	(735)	(419)
Loss on convertible senior notes conversion			(7,791)
Loss on extinguishment of debt	(3,277)		(3,277)
Legal settlement loss		(25,000)		(25,000)
Other income	239	1,899	1,081	4,300
Other income (expense), net	(9,635)	(27,144)	(27,022)	(28,526)
Loss before income taxes	(92,283)	(120,603)	(191,683)	(207,186)
Income tax benefit	36	176	104	336
Net loss	(92,247)	(120,427)	(191,579)	(206,850)
Other comprehensive income (loss):
Foreign currency translation adjustments, net of tax	61	(1)	(42)	(6)
Net unrealized gain on available-for-sale securities, net of tax	(84)	77	(6)	152
Other comprehensive (loss) income:	(23)	76	(48)	146
Comprehensive loss	$ (92,270)	$ (120,351)	$ (191,627)	$ (206,704)
Loss per basic and diluted common share:
Basic and diluted net loss per common share	$ (1.15)	$ (2.27)	$ (2.52)	$ (3.91)
Basic and diluted weighted average common shares outstanding	80,453	53,028	76,057	52,960
Product
Operating expenses:
Cost of sales	$ 9,120	$ 6,445	$ 18,216	$ 13,851
Intangible assets amortization
Operating expenses:
Cost of sales	$ 1,280	$ 1,217	$ 2,492	$ 2,337