CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2020	Mar. 31, 2019
Operating activities
Net loss	$ (99,332)	$ (86,421)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	12,961	13,640
Depreciation and amortization	2,130	1,722
Amortization of premiums and discounts on available-for-sale securities	(140)	(129)
Amortization of debt issuance costs	786	645
Write-off of debt issuance costs related to convertible senior notes conversion	3,555
Loss on convertible senior notes conversion	7,791
Changes in operating assets and liabilities:
Accounts receivable	(4,519)	(3,205)
Inventory	6,839	(23,936)
Prepaid and accrued research and development expenses	(5,559)	3,437
Deposit on inventory	(12,373)
Other operating assets and liabilities	5,198	(4,901)
Accounts payable	4,016	5,389
Other accrued expenses	(3,847)	(4,692)
Net cash used in operating activities	(82,494)	(98,451)
Investing activities
Purchases of property and equipment	(34)	(1,231)
Purchases of available-for-sale securities	(9,962)	(138,415)
Sales of available-for-sale securities	79,803	153,500
Acquired in-process research and development - milestone payment		(15,000)
Net cash provided by (used in) investing activities	69,807	(1,146)
Financing activities
Proceeds from the sale of common stock, net of issuance costs	163,901
Payment of convertible senior notes	(164,443)
Proceeds from borrowings under financing agreement	15,592
Proceeds from the exercise of stock options and employee stock purchases	2	1,093
Payments on finance leases	(357)	(250)
Payments on other long-term liabilities	(51)
Net cash provided by financing activities	14,644	1,093
Effect of exchange rate changes on cash and cash equivalents	(481)	(64)
Increase (decrease) in cash and cash equivalents	1,476	(98,568)
Cash and cash equivalents at beginning of period	161,833	221,876
Cash and cash equivalents at end of period	163,309	123,308
Supplemental disclosure of cash flow information:
Cash paid for interest	4,131	3,594
Non-cash investing and financing activities:
Vesting of restricted stock units	$ 5,461	$ 3,277

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