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Share-Based Compensation - Summary of Stock Options Activity (Details)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2020
USD ($)
$ / shares
shares
Share-Based Compensation  
Beginning Balance, Number of Options Outstanding | shares 6,287,025
Number of Options, Granted | shares 471,250
Number of Options, Exercised | shares (759)
Number of Options, Forfeited | shares (198,760)
Ending Balance, Number of Options Outstanding | shares 6,558,756
Vested and expected to vest at March 31, 2020 | shares 6,412,785
Vested and exercisable at March 31, 2020 | shares 4,808,471
Beginning Balance, Weighted Average Exercise Price | $ / shares $ 42.24
Granted, Weighted Average Exercise Price | $ / shares 8.49
Exercised, Weighted Average Exercise Price | $ / shares 3.14
Forfeited, Weighted Average Exercise Price | $ / shares 49.86
Ending Balance, Weighted Average Exercise Price | $ / shares 39.58
Vested and expected to vest, Weighted Average Exercise Price | $ / shares 39.84
Vested and exercisable, Weighted Average Exercise Price | $ / shares $ 44.68
Outstanding, Weighted Average Remaining Contractual Term (Years) 6 years 1 month 6 days
Vested and expected to vest, Weighted Average Remaining Contractual Term (Years) 6 years
Exercisable, Weighted Average Remaining Contractual Term (Years) 5 years 1 month 6 days
Outstanding at March 31, 2020, Aggregate Intrinsic Value | $ $ 731
Vested and expected to vest at March 31, 2020, Aggregate Intrinsic Value | $ 704
Vested and exercisable at March 31, 2020, Aggregate Intrinsic Value | $ $ 387