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Long-term Debt (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
May 02, 2022
D
Aug. 13, 2019
USD ($)
$ / shares
May 01, 2019
USD ($)
site
item
country
Apr. 16, 2018
USD ($)
$ / shares
Sep. 09, 2014
USD ($)
item
D
$ / shares
May 31, 2020
USD ($)
shares
Mar. 31, 2020
USD ($)
May 05, 2020
USD ($)
Apr. 30, 2020
USD ($)
Dec. 31, 2019
USD ($)
Debt Instrument                    
Aggregate principal amount             $ 536,046      
2019                    
Debt Instrument                    
Repayments of Debt             35,000      
2020                    
Debt Instrument                    
Repayments of Debt             $ 50,000      
Date is prior to Repayment Start Date                    
Debt Instrument                    
Debt Instrument Ratio of borrowed amount             1.75%      
Date is after Repayment Start Date                    
Debt Instrument                    
Debt Instrument Ratio of borrowed amount             2.00%      
TPG Sixth Street Partners, LLC                    
Debt Instrument                    
Principal amount outstanding             $ 52,400      
Debt issuance costs             1,800      
Unamortized debt issuance costs             $ 1,600      
Number of patients | item     1,000              
Number of countries | country     25              
Effective interest rate             14.50%      
Debt, Weighted Average Interest Rate     9.75%       10.25%      
Maximum Amount to be Repaid Under Borrowing Agreement     $ 166,500              
Percentage of royalty payment received     19.50%              
Percentage of other amounts received     19.50%              
Quarterly payments based on a certain percentage of revenues             $ 8,500      
Quarterly payments with label portion expanded by FDA             13,500      
Aggregate borrowed amount     $ 166,500              
Ratio of repayment amount     2              
TPG Sixth Street Partners, LLC | Minimum                    
Debt Instrument                    
Number of sites | site     270              
TPG Sixth Street Partners, LLC | Maximum                    
Debt Instrument                    
Aggregate principal amount     $ 175,000              
Maximum Amount to be Repaid Under Borrowing Agreement     350,000              
Aggregate borrowed amount     $ 350,000              
Convertible Senior Unsecured Notes                    
Debt Instrument                    
Unamortized debt issuance costs             $ 11,100     $ 15,400
2021 Notes                    
Debt Instrument                    
Convertible senior notes, interest rate         2.50%   2.50%      
Aggregate principal amount         $ 287,500   $ 97,188      
Convertible senior notes, maturity date         Sep. 15, 2021   Sep. 15, 2021      
Net proceeds from convertible senior notes         $ 278,300          
Common stock initial conversion rate per $1,000 in principal amount         16.1616          
Convertible senior notes, initial conversion price per share | $ / shares         $ 61.88          
Debt instrument, redemption period start date         Sep. 15, 2018          
Last reported sale price of common stock as a percent of conversion price         150.00%          
Debt instrument, conversion in effect for number of trading days | D         20          
Debt instrument conversion, consecutive trading day period | D         30          
Debt instrument, trading days preceding redemption notice, maximum | item         2          
Debt instrument redemption price percentage to principal amount         100.00%          
Debt instrument repurchase percentage         100.00%          
Principal amount outstanding   $ 190,300                
Aggregate repurchase price including accrued interest   171,800                
Gain on extinguishment of debt   18,500                
Debt issuance costs         $ 9,200          
Unamortized debt issuance costs derecognized   $ 2,000                
Debt instrument term         7 years          
2021 Notes | Subsequent Event                    
Debt Instrument                    
Aggregate principal amount                 $ 32,800  
Principal amount outstanding                 64,400  
2021 Notes | Semi Annual Payment, First payment date                    
Debt Instrument                    
Interest payment date on senior notes         --03-15          
2021 Notes | Semi Annual Payment, Second payment date                    
Debt Instrument                    
Interest payment date on senior notes         --09-15          
2024 Notes                    
Debt Instrument                    
Convertible senior notes, interest rate   4.50%         4.50%      
Aggregate principal amount   $ 263,000         $ 138,858      
Convertible senior notes, maturity date             Aug. 01, 2024      
Net proceeds from convertible senior notes   $ 254,900                
Common stock initial conversion rate per $1,000 in principal amount   137.2213                
Convertible senior notes, initial conversion price per share | $ / shares   $ 7.29                
Debt instrument repurchase percentage   100.00%                
Debt issuance costs   $ 8,000                
Debt instrument term   5 years                
2024 Notes | Subsequent Event                    
Debt Instrument                    
Aggregate principal amount           $ 24,300     $ 36,100  
Common stock initial conversion rate per $1,000 in principal amount           137.2213        
Principal amount outstanding               $ 150,600    
Debt conversion to number of shares of common stock | shares           3,331,047        
2024 Notes | Semi Annual Payment, First payment date                    
Debt Instrument                    
Interest payment date on senior notes   --02-01                
2024 Notes | Semi Annual Payment, Second payment date                    
Debt Instrument                    
Interest payment date on senior notes   --08-01                
2025 Notes                    
Debt Instrument                    
Convertible senior notes, interest rate       1.25%     1.25%      
Aggregate principal amount       $ 300,000     $ 300,000      
Convertible senior notes, maturity date             May 01, 2025      
Net proceeds from convertible senior notes       $ 290,900            
Common stock initial conversion rate per $1,000 in principal amount       13.1278            
Convertible senior notes, initial conversion price per share | $ / shares       $ 76.17            
Debt instrument repurchase percentage       100.00%            
Debt issuance costs       $ 9,100            
Debt instrument term       7 years            
2025 Notes | Semi Annual Payment, First payment date                    
Debt Instrument                    
Interest payment date on senior notes       --05-01            
2025 Notes | Semi Annual Payment, Second payment date                    
Debt Instrument                    
Interest payment date on senior notes       --11-01            
Borrowing Exceeds $166.5 million | TPG Sixth Street Partners, LLC | Minimum                    
Debt Instrument                    
Quarterly payments based on a certain percentage of revenues             $ 8,940      
Borrowing Exceeds $166.5 million | TPG Sixth Street Partners, LLC | Maximum                    
Debt Instrument                    
Quarterly payments with label portion expanded by FDA             $ 14,190      
Scenario, Actual | 2025 Notes                    
Debt Instrument                    
Last reported sale price of common stock as a percent of conversion price 150.00%                  
Debt instrument, conversion in effect for number of trading days | D 20                  
Debt instrument conversion, consecutive trading day period | D 30                  
Debt instrument, trading days preceding redemption notice, maximum | D 2                  
Debt instrument redemption price percentage to principal amount 100.00%