Share-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2020

Share-Based Compensation

Share-Based Compensation Expense Recognized in Accompanying Statements of Operations

Share-based compensation expense for all equity-based programs, including stock options, restricted stock units and the employee stock purchase plan, for the three months ended March 31, 2020 and 2019 was recognized in the accompanying Consolidated Statements of Operations and Comprehensive Loss as follows (in thousands):

	Three months ended March 31,
	2020		2019
Research and development	$	6,925	$	6,611
Selling, general and administrative		6,036		7,029
Total share-based compensation expense	$	12,961	$	13,640

Summary of Stock Options Activity

				Weighted
		Weighted		Average	Aggregate
		Average		Remaining	Intrinsic
	Number of	Exercise		Contractual	Value
	Options	Price		Term (Years)	(Thousands)
Outstanding at December 31, 2019	6,287,025	$	42.24
Granted	471,250		8.49
Exercised	(759)		3.14
Forfeited	(198,760)		49.86
Outstanding at March 31, 2020	6,558,756	$	39.58	6.1	$	731
Vested and expected to vest at March 31, 2020	6,412,785	$	39.84	6.0	$	704
Vested and exercisable at March 31, 2020	4,808,471	$	44.68	5.1	$	387

Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award

The following table summarizes information about our stock options as of and for the three months ended March 31, 2020 and 2019 (in thousands, except per share amounts):

	Three months ended March 31,
	2020		2019
Weighted-average grant date fair value per share	$	6.55	$	18.83
Intrinsic value of options exercised	$	4	$	765
Cash received from stock option exercises	$	2	$	1,094

Summary of activity related to our unvested RSUs

		Weighted
		Average
	Number of	Grant Date
	Units	Fair Value
Unvested at December 31, 2019	2,171,347	$	28.37
Granted	2,368,303		8.29
Vested	(662,323)		27.19
Forfeited	(111,943)		25.04
Unvested at March 31, 2020	3,765,384	$	16.04
Expected to vest after March 31, 2020	3,569,090	$	15.45