CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues:
Product revenue	$ 42,564	$ 33,118
Product revenue - extensible list	us-gaap:ProductMember	us-gaap:ProductMember
Operating expenses:
Research and development	$ 68,221	$ 62,031
Selling, general and administrative	42,598	47,761
Other operating expenses	3,449
Total expenses	124,576	118,317
Operating loss	(82,012)	(85,199)
Other income (expense):
Interest expense	(9,561)	(3,590)
Foreign currency loss	(877)	(192)
Loss on convertible senior notes conversion	(7,791)
Other income	841	2,400
Other income (expense), net	(17,388)	(1,382)
Loss before income taxes	(99,400)	(86,581)
Income tax benefit	68	160
Net loss	(99,332)	(86,421)
Other comprehensive income (loss):
Foreign currency translation adjustments, net of tax	(103)	(5)
Net unrealized gain on available-for-sale securities, net of tax	78	75
Other comprehensive (loss) income:	(25)	70
Comprehensive loss	$ (99,357)	$ (86,351)
Loss per basic and diluted common share:
Basic and diluted net loss per common share	$ (1.39)	$ (1.63)
Basic and diluted weighted average common shares outstanding	71,662	52,891
Product
Operating expenses:
Cost of sales	$ 9,096	$ 7,405
Intangible assets amortization
Operating expenses:
Cost of sales	$ 1,212	$ 1,120