CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 201,481	$ 221,876
Accounts receivable, net	16,816	12,889
Inventories, net	24,864	27,072
Available-for-sale securities	152,622	298,270
Prepaid research and development expenses	4,597	3,579
Other current assets	18,095	8,613
Total current assets	418,475	572,299
Inventories	97,221	113,908
Deposit on inventory	12,350	12,350
Property and equipment, net	15,223	26,524
Right-of-use assets, net	25,427
Intangible assets, net	64,132	51,930
Goodwill	63,074	63,074
Other assets	20,990	23,475
Total assets	716,892	863,560
Current liabilities:
Accounts payable	31,655	28,517
Accrued research and development expenses	43,981	29,676
Lease liabilities	4,458
Other accrued expenses	31,266	67,556
Total current liabilities	111,360	125,749
Long-term lease liabilities - less current portion	27,768
Convertible senior notes	644,095	575,470
Borrowings under financing agreement	19,944
Other long-term liabilities	1,220	15,872
Total liabilities	804,387	717,091
Commitments and contingencies (Note 15)
Stockholders' equity:
Preferred stock, par value $0.001 per share; 10,000,000 shares authorized, no shares issued and outstanding at September 30, 2019 and December 31, 2018
Common stock, $0.001 par value per share, 200,000,000 and 100,000,000 shares authorized at September 30, 2019 and December 31, 2018, respectively; 54,805,525 and 52,797,516 shares issued and outstanding at September 30, 2019 and December 31, 2018, respectively	55	53
Additional paid-in capital	2,101,162	2,034,142
Accumulated other comprehensive loss	(44,699)	(44,634)
Accumulated deficit	(2,144,013)	(1,843,092)
Total stockholders' equity (deficit)	(87,495)	146,469
Total liabilities and stockholders' equity (deficit)	$ 716,892	$ 863,560