CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenues:
Product revenue	$ 37,603	$ 22,757	$ 103,699	$ 65,037
Product revenue - extensible list	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Operating expenses:
Research and development	$ 77,896	$ 63,887	$ 210,674	$ 160,138
Selling, general and administrative	41,811	42,495	137,601	126,634
Acquired in-process research and development	9,440		9,440
Other operating expenses	5,539		5,539
Total expenses	144,032	111,919	388,787	301,885
Operating loss	(106,429)	(89,162)	(285,088)	(236,848)
Other income (expense):
Interest expense	(5,278)	(3,376)	(12,684)	(9,592)
Foreign currency (loss) gain	(229)	151	(648)	(34)
Legal settlement loss	(1,750)		(26,750)	(27,975)
Gain on extinguishment of debt	18,480		18,480
Other income	781	2,536	5,081	5,419
Other expense, net	12,004	(689)	(16,521)	(32,182)
Loss before income taxes	(94,425)	(89,851)	(301,609)	(269,030)
Income tax benefit (expense)	350	(13)	686	280
Net loss	(94,075)	(89,864)	(300,923)	(268,750)
Other comprehensive income (loss):
Foreign currency translation adjustments, net of tax	(143)	(495)	(149)	(2,448)
Net unrealized gain (loss) on available-for-sale securities, net of tax	(68)	(10)	84	71
Other comprehensive (loss) income:	(211)	(505)	(65)	(2,377)
Comprehensive loss	$ (94,286)	$ (90,369)	$ (300,988)	$ (271,127)
Loss per basic and diluted common share:
Basic and diluted net loss per common share	$ (1.72)	$ (1.71)	$ (5.62)	$ (5.18)
Basic and diluted weighted average common shares outstanding	54,707	52,669	53,549	51,844
Product
Operating expenses:
Cost of sales	$ 8,134	$ 4,766	$ 21,984	$ 13,262
Intangible assets amortization
Operating expenses:
Cost of sales	$ 1,212	$ 771	$ 3,549	$ 1,851