Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016
Operating activities
Net loss	$ (294,514)	$ (278,409)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	32,201	29,744
Depreciation and amortization	1,911	819
Amortization of premiums and discounts on available-for-sale securities	6	190
Amortization of debt issuance costs	956	928
Legal settlement loss, net of insurance receivable	117,000
Impairment of intangible asset		104,517
Change in fair value of contingent purchase consideration	0	(24,661)
Loss on disposal of property and equipment	0	105
Deferred income taxes	(2,403)	(33,320)
Changes in operating assets and liabilities:
Accounts receivable	121	0
Inventory	(5,345)	0
Prepaid and accrued research and development expenses	(16,284)	(14,877)
Deposit on inventory	(31,818)
Other operating assets	(4,156)	2,358
Accounts payable	5,050	(322)
Other accrued expenses	1,949	923
Net cash used in operating activities	(195,326)	(212,005)
Investing activities
Purchases of property and equipment	(416)	(761)
Deposits for purchases of property and equipment	(2,515)	65
Purchases of available-for-sale securities	(180,000)	0
Maturities of available-for-sale securities	213,500	175,000
Acquired in-process research and development - milestone payment	(1,100)	0
Net cash provided by investing activities	29,469	174,304
Financing activities
Proceeds from the sale of common stock, net of issuance costs	545,838	0
Proceeds from the exercise of stock options and employee stock purchases	14,419	2,602
Net cash provided by financing activities	560,257	2,602
Effect of exchange rate changes on cash and cash equivalents	886	67
Increase (decrease) in cash and cash equivalents	395,286	(35,032)
Cash and cash equivalents at beginning of period	216,186	278,756
Cash and cash equivalents at end of period	611,472	243,724
Supplemental disclosure of cash flow information:
Cash paid for interest	7,188	7,188
Non-cash investing and financing activities:
Vesting of restricted stock units	$ 9,449	$ 157