Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Product revenue, net	$ 16,806		$ 38,471	$ 0
Operating expenses:
Cost of sales - product	3,026		6,920	0
Cost of sales - intangible asset amortization	372		1,115	0
Research and development	38,924	$ 54,338	104,479	196,675
Selling, general and administrative	35,011	9,162	100,384	28,541
Acquired in-process research and development		500		800
Impairment of intangible asset				104,517
Change in fair value of contingent purchase consideration			0	(24,936)
Total expenses	77,333	64,000	212,898	305,597
Operating loss	(60,527)	(64,000)	(174,427)	(305,597)
Other income (expense):
Interest expense	(2,618)	(2,108)	(7,796)	(6,318)
Foreign currency loss	(44)	(66)	(127)	(434)
Legal settlement loss, net of insurance receivable			(117,000)
Other income	1,291	252	2,237	473
Other expense, net	(1,371)	(1,922)	(122,686)	(6,279)
Loss before income taxes	(61,898)	(65,922)	(297,113)	(311,876)
Income tax benefit	1,234	227	2,599	33,467
Net loss	(60,664)	(65,695)	(294,514)	(278,409)
Other comprehensive income:
Foreign currency translation adjustments, net of tax	1,595	58	4,874	2,190
Net unrealized gain (loss) on available-for-sale securities, net of tax	10	(18)	5	260
Other comprehensive income	1,605	40	4,879	2,450
Comprehensive loss	$ (59,059)	$ (65,655)	$ (289,635)	$ (275,959)
Net Loss Per Common Share
Basic and diluted net loss per common share	$ (1.24)	$ (1.70)	$ (6.39)	$ (7.24)
Basic and diluted weighted average common shares outstanding	48,917	38,538	46,062	38,429