Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Product revenue, net	$ 7,045	$ 0
Operating expenses:
Cost of sales - product	1,163	0
Cost of sales - intangible asset amortization	372	0
Research and development	32,447	74,608
Selling, general and administrative	29,224	9,827
Change in fair value of contingent purchase consideration	0	516
Total expenses	63,206	84,951
Operating loss	(56,161)	(84,951)
Other income (expense):
Interest expense	(2,581)	(2,104)
Foreign currency losses	(159)	(551)
Other income	354	25
Other income (expense), net	(2,386)	(2,630)
Loss before income taxes	(58,547)	(87,581)
Income tax benefit	83	4,181
Net loss	(58,464)	(83,400)
Other comprehensive income
Foreign currency translation adjustments, net of tax	467	3,513
Net unrealized (loss) gain on available-for-sale securities, net of tax	(5)	230
Other comprehensive income	462	3,743
Comprehensive loss	$ (58,002)	$ (79,657)
Loss per basic and diluted common share:
Basic and diluted net loss per common share	$ (1.33)	$ (2.17)
Basic and diluted weighted average common shares outstanding	44,039	38,360