X0306 4 2018-03-22 0 0001717452 Odonate Therapeutics, Inc. ODT 0001465914 Davis Aaron I. 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO CA 92130 1 0 1 0 Common Stock 2018-03-22 4 P 0 23407 20.94 A 2750345 I See Footnote Common Stock 2018-03-23 4 P 0 42943 23.96 A 2793288 I See Footnote Common Stock 2018-03-26 4 P 0 33650 22.41 A 2826938 I See Footnote Common Stock 645756 D The reporting person effected multiple same-way open market purchases on the same day at different prices through multiple trade orders. The price in the table reflects the weighted average purchase price of such trades on such date. These shares were purchased at prices ranging from $20.76 to $21.16 per share. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares purchased at each separate price. These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), and indirectly by the reporting person, Boxer Asset Management Inc. ("Boxer Management") and Joe Lewis, by virtue of their ownership in Boxer Capital. The reporting person may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Management, (iii) the reporting person, and (iv) Joe Lewis (collectively, the "Boxer Group"). Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it does not have a pecuniary interest therein. These securities are owned directly by the reporting person. Each member of the Boxer Group other than the reporting person disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. s/ Aaron Davis 2018-03-26