X0306 4 2021-09-17 0 0001863127 Tyra Biosciences, Inc. TYRA 0001465837 Boxer Capital, LLC 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 0 0 1 0 0001465836 Boxer Asset Management Inc. C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE C5 N7776 BAHAMAS 0 0 1 0 0001015747 LEWIS JOSEPH C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE C5 BAHAMAS 0 0 1 0 0001468223 MVA Investors, LLC 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 0 0 1 0 0001465914 Davis Aaron I. 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 0 0 1 0 Common Stock 2021-09-17 4 C 0 5698359 A 5698359 D Common Stock 2021-09-17 4 P 0 625000 16.00 A 6323359 D Common Stock 2021-09-17 4 C 0 288095 A 288095 D Series A Preferred Stock 2021-09-17 4 C 0 1480242 0.00 D Common Stock 3844780 0 D Series A Preferred Stock 2021-09-17 4 C 0 95516 0.00 D Common Stock 248093 0 D Series B Preferred Stock 2021-09-17 4 C 0 713629 0.00 D Common Stock 1853579 0 D Series B Preferred Stock 2021-09-17 4 C 0 15401 0.00 D Common Stock 40002 0 D On September 17, 2021, each share of Series A Preferred Stock and each share of Series B Preferred Stock converted into shares of the Issuer's common stock at a ratio of 1-for-2.5974 without payment of further consideration upon closing of the initial public offering of the Issuer's common stock. The shares had no expiration date. These securities are held directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) Joseph C. Lewis, (iv) MVA Investors, LLC and (v) Aaron I. Davis (collectively, the "Boxer Group"), and indirectly by Boxer Management and Joseph C. Lewis by virtue of their ownership in Boxer Capital. Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. These securities are held directly by MVA Investors, which may be deemed to be a member of the Boxer Group for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, and indirectly by Mr. Davis who is a member of and has voting and dispositive power over securities held by MVA Investors. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. Boxer Capital, LLC, By: /s/ Aaron I. Davis, Aaron I. Davis, Chief Executive Officer 2021-09-17 Boxer Asset Management Inc., By: /s/ Jason C. Callender, Jason C. Callender, Director 2021-09-17 /s/ Joseph C. Lewis 2021-09-17 MVA Investors, LLC, By: /s/ Aaron I. Davis, Aaron I. Davis, Chief Executive Officer 2021-09-17 /a/ Aaron I. Davis 2021-09-17