X0306 4 2020-12-28 0 0001717452 Odonate Therapeutics, Inc. ODT 0001465837 Boxer Capital, LLC 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 1 0 1 0 0001465836 Boxer Asset Management Inc. C/O CAY HOUSE, EP TAYLOR DRIVE N7776 LYFORD CAY NEW PROVIDENCE C5 BAHAMAS 0 0 1 0 0001015747 LEWIS JOSEPH C/O CAY HOUSE, EP TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE C5 N7776 BAHAMAS 0 0 1 0 Common Stock 2020-12-28 4 P 0 75000 16.90 A 5282086 D Common Stock 2020-12-28 4 P 0 225000 17.1091 A 5507086 D Common Stock 2020-12-30 4 P 0 100000 17.4638 A 5607086 D These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) Aaron I. Davis, and (iv) Joseph C. Lewis (collectively, the "Boxer Group"). Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. These securities are owned indirectly by Boxer Management and Joseph C. Lewis, by virtue of their ownership of Boxer Capital. Reflects the weighted average purchase price. The reporting person effected multiple same-way open market purchase transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person reported on a single line all such transactions that occurred within a one dollar price range. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares purchased at each separate price. The range of prices for such transaction is $16.75 to $17.29. Reflects the weighted average purchase price. The reporting person effected multiple same-way open market purchase transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person reported on a single line all such transactions that occurred within a one dollar price range. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares purchased at each separate price. The range of prices for such transaction is $16.89 to $17.72. Boxer Capital, LLC, By: /s/ Aaron Davis, Aaron Davis, Chief Executive Officer 2020-12-30 Boxer Asset Management Inc., By: /s/ Jason Callender, Jason Callender, Director 2020-12-30 Joseph C. Lewis, /s/ Joseph C. Lewis, Joseph C. Lewis 2020-12-30