<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2018-10-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001434868</issuerCik>
        <issuerName>Esperion Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>ESPR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001642355</rptOwnerCik>
            <rptOwnerName>Braslyn Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CAY HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2>EP TAYLOR DRIVE N7776, LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001465836</rptOwnerCik>
            <rptOwnerName>Boxer Asset Management Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CAY HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2>EP TAYLOR DRIVE N7776, LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001723227</rptOwnerCik>
            <rptOwnerName>Tuesday Thirteen Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CAY HOUSE,</rptOwnerStreet1>
            <rptOwnerStreet2>EP TAYLOR DRIVE N7776, LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001015747</rptOwnerCik>
            <rptOwnerName>LEWIS JOSEPH</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CAY HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2>EP TAYLOR DRIVE N7776, LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001465837</rptOwnerCik>
            <rptOwnerName>Boxer Capital, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>11682 EL CAMINO REAL, SUITE 320</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1401000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1201250</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>100</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Call Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>50.00</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2018-10-25</value>
            </exerciseDate>
            <expirationDate>
                <value>2019-03-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Call Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>60.00</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2018-10-25</value>
            </exerciseDate>
            <expirationDate>
                <value>2019-03-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>70000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These securities are owned directly by Braslyn Ltd. (&quot;Braslyn&quot;), which may be deemed to be a member of a &quot;group&quot; for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Braslyn, (ii) Boxer Capital, LLC (&quot;Boxer Capital&quot;), (iii) Boxer Asset Management Inc. (&quot;Boxer Management&quot;), (iv) Tuesday Thirteen Inc. (&quot;Tuesday Thirteen&quot;) and (v) Joseph C. Lewis (collectively, the &quot;Boxer Group&quot;), and indirectly by Joseph C. Lewis. Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it does not have a pecuniary interest therein.</footnote>
        <footnote id="F2">These securities are owned directly by Boxer Capital and indirectly by Boxer Management and Joseph C. Lewis.</footnote>
        <footnote id="F3">These securities are owned directly by Tuesday Thirteen and indirectly by Joseph C. Lewis.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Braslyn Ltd., By: /s/ Joseph C. Lewis, Director</signatureName>
        <signatureDate>2018-10-30</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Boxer Capital, LLC, By:	/s/ Aaron I. Davis, Chief Executive Officer</signatureName>
        <signatureDate>2018-10-30</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Boxer Asset Management Inc., By: /s/ Jason C. Callender, Director</signatureName>
        <signatureDate>2018-10-30</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Tuesday Thirteen Inc., By: /s/ Joseph C. Lewis, Director</signatureName>
        <signatureDate>2018-10-30</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Joseph C. Lewis</signatureName>
        <signatureDate>2018-10-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
