<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2016-01-04</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001576263</issuerCik>
        <issuerName>Mirati Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>MRTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001603577</rptOwnerCik>
            <rptOwnerName>Berkley Capital Management Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAY HOUSE P.O. BOX N-7776</rptOwnerStreet1>
            <rptOwnerStreet2>E.P. TAYLOR DRIVE LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001642355</rptOwnerCik>
            <rptOwnerName>Braslyn Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAY HOUSE, P.O. BOX N-7776</rptOwnerStreet1>
            <rptOwnerStreet2>E.P. TAYLOR DRIVE LYFORD</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001465836</rptOwnerCik>
            <rptOwnerName>Boxer Asset Management Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAY HOUSE P.O. BOX N-7776</rptOwnerStreet1>
            <rptOwnerStreet2>E.P. TAYLOR DRIVE LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001015747</rptOwnerCik>
            <rptOwnerName>LEWIS JOSEPH</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAY HOUSE P.O. BOX N-7776</rptOwnerStreet1>
            <rptOwnerStreet2>E.P. TAYLOR DRIVE LYFORD CAY</rptOwnerStreet2>
            <rptOwnerCity>NEW PROVIDENCE</rptOwnerCity>
            <rptOwnerState>C5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>BAHAMAS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001465837</rptOwnerCik>
            <rptOwnerName>Boxer Capital, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>440 STEVENS AVE, SUITE 100</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SOLANA BEACH</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92075</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001468223</rptOwnerCik>
            <rptOwnerName>MVA Investors, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>440 STEVENS AVE, SUITE 100</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SOLANA BEACH</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92075</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2016-01-04</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>522500</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2023232</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>522500</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>429340</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F5"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">On January 4, 2016, Berkley Capital Management Ltd.(&quot;Berkley Capital&quot;) transferred certain of its assets, including all of its shares of common stock of the issuer, to Braslyn for no consideration as part of an internal reorganization.</footnote>
        <footnote id="F2">These securities are owned directly by Berkley Capital, which may be deemed to be a member of a &quot;group&quot; for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Berkley Capital, (ii) Braslyn Ltd. (&quot;Braslyn&quot;), (iii) Boxer Capital, (iv) Boxer Asset Management Inc. (&quot;Boxer Management&quot;), (v) MVA Investors, LLC (&quot;MVA Investors&quot;), and (vi)  Joe Lewis (collectively, the &quot;Boxer Group&quot;).  Joe Lewis is the sole indirect owner of and controls Berkley Capital.</footnote>
        <footnote id="F3">These securities are owned directly by Boxer Capital, and indirectly by Boxer Management and Joe Lewis, by virtue of their ownership in Boxer Capital.</footnote>
        <footnote id="F4">These securities are owned directly by Braslyn, and indirectly by Joe Lewis.  Joe Lewis is the sole indirect owner of and controls Braslyn.</footnote>
        <footnote id="F5">These securities are owned directly and solely by MVA Investors, which has sole voting and dispositive power with respect to these securities. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Boxer Capital, LLC, By: /s/ Aaron Davis, Aaron Davis</signatureName>
        <signatureDate>2016-01-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Boxer Asset Management Inc., By: /s/ Jefferson Voss, Jefferson Voss</signatureName>
        <signatureDate>2016-01-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>MVA Investors, LLC, By: /s/ Aaron Davis, Aaron Davis</signatureName>
        <signatureDate>2016-01-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Joseph Lewis, /s/ Joseph Lewis, Joseph Lewis</signatureName>
        <signatureDate>2016-01-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Berkley Capital Management Ltd., By: /s/ Jefferson R. Voss, Jefferson R. Voss</signatureName>
        <signatureDate>2016-01-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Braslyn Ltd., By: /s/ Jefferson R. Voss, Jefferson R. Voss</signatureName>
        <signatureDate>2016-01-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
