X0609 4 2026-09-11 0001464521 Heartflow, Inc. HTFL 0002079946 Verghese Vikram false C/O HEARTFLOW, INC. 135 MAIN STREET, SUITE 1000 SAN FRANCISCO CA 94105 1 Chief Financial Officer 1 Common Stock. 2026-09-11 4 S 0 29714 50.0592 D 184789 D Common Stock. 2026-09-14 4 S 0 4593 50.2381 D 180196 D Common Stock. 2026-09-15 4 S 0 668 50.012 D 179528 D The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 4, 2026. This transaction was executed in multiple trades at price ranging from $50.06 to $50.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at price ranging from $50.00 to $50.62. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at price ranging from $50.00 to $50.04. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ Nga Van, by power of attorney 2026-09-15