X0609 4 2026-03-19 0001464521 Heartflow, Inc. HTFL 0001585724 Rogers Campbell false C/O HEARTFLOW, INC. 331 E. EVELYN AVENUE MOUNTAIN VIEW CA 94041 1 Chief Medical Officer 1 Common Stock 2026-03-19 4 M 0 19402 2.22 A 95436 D Common Stock 2026-03-19 4 M 0 47615 2.22 A 143051 D Common Stock 2026-03-19 4 S 0 64533 25.6928 D 78518 D Common Stock 22615 I By Campbell Rogers 2019 Irrevocable Trust Common Stock 46159 I By CR Asset Protection Trust of 2023 Common Stock 26012 I By Spouse's Trust Common Stock 50754 I By The Campbell Rogers Revocable Trust Stock Option 2.22 2026-03-19 4 M 0 19402 0 D 2033-07-10 Common Stock 19402 189125 D Stock Option 2.22 2026-03-19 4 M 0 47615 0 D 2033-07-10 Common Stock 47615 141510 D The option exercise reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on September 12, 2025. The option exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on September 12, 2025. Includes the sale of 16,918 shares of common stock held and the option exercise and sale of 47,615 shares reported on this Form 4 that were effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on September 12, 2025. This transaction was executed in multiple trades at price ranging from $25.00 to $28.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The option vests and becomes exercisable in monthly installments until July 1, 2027, subject to continued service through the applicable vesting date. /s/ Nga Van, by power of attorney 2026-03-23