X0306 4 2022-11-18 0 0001463361 Unity Biotechnology, Inc. UBX 0001727640 Sullivan Lynne Marie C/O UNITY BIOTECHNOLOGY, INC. 285 EAST GRAND AVENUE SOUTH SAN FRANCISCO CA 94080 0 1 0 0 CFO & Head of Corp. Dev. Common Stock, $0.0001 par value 2022-05-15 5 J 0 E 925 6.89 A 33009 D Stock Option (Right to Buy) 2.38 2022-11-18 4 A 0 80000 0.00 A 2032-11-18 Common Stock 80000 80000 D The reporting person is voluntarily reporting the acquisition of shares of the issuer's common stock pursuant to the Unity Biotechnology, Inc. 2018 Employee Stock Purchase Plan (the ESPP). The acquisition of those 925 shares was also exempt pursuant to Rule 16b-3(c). In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the Issuer's common stock on May 15, 2022. Includes RSUs which vest over time measured from the grant date. Reflects a 1-for-10 reverse stock split of the Issuer's common stock, effected by the Issuer on October 19, 2022, which was exempt from reporting pursuant to Rule 16a-9. The underlying shares vest and become exercisable pursuant to the following schedule: One-eighth of the shares subject to the option vest in successive, equal quarterly installments starting on February 18, 2023, subject to the Reporting Person's continued service to Issuer through the applicable vesting date. /s/ Alexander Nguyen, Attorney-in-Fact for Lynne Marie Sullivan 2022-11-21