X0306 4 2022-03-14 0 0001463361 Unity Biotechnology, Inc. UBX 0001807437 Ghosh Anirvan C/O UNITY BIOTECHNOLOGY, INC. 285 EAST GRAND AVENUE SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Executive Officer Common Stock, $0.0001 par value 2022-03-14 4 F 0 9272 0.88 D 1054395 D Shares sold by the Reporting Person pursuant to a Rule 10b5-1 trading instruction to cover tax withholding obligations incurred in connection with the vesting of Restricted Stock Units. Includes Restricted Stock Units which vest over time measured from the grant date. /s/ Anirvan Ghosh 2022-03-15