X0306 4 2020-06-22 0 0001463361 Unity Biotechnology, Inc. UBX 0001416180 Leonard Keith R C/O UNITY BIOTECHNOLOGY, INC. 285 EAST GRAND AVENUE SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock, $0.0001 par value 2020-06-22 4 F 0 4711 9.67 D 89546 D Common Stock, $0.0001 par value 500000 I See Footnote Common Stock, $0.0001 par value 148448 I See Footnote Common Stock, $0.0001 par value 152542 I See Footnote The shares were withheld at the election of the Reporting Person to satisfy tax withholding obligations in connection with the release of shares subject to vesting. Includes Restricted Stock Units which vest over time measured from the grant date. The shares are held by Keith Richard Leonard, Jr. 2019 Retained Annuity Trust dated 16 Dec 2019. The shares are held by Pathfinder Investment Fund, LLC, a limited liability company in which the Reporting Person holds a controlling interest. The shares are held by Keith Richard Leonard, Jr. 2017 Retained Annuity Trust. /s/ Tamara L. Tompkins, Attorney-in-Fact for Keith R. Leonard 2020-06-24