SCHEDULE 13G 0001462830 XXXXXXXX LIVE Common Stock, Par Value $0.0001 Per Share 12/11/2025 0001585608 Jaguar Health, Inc. 47010C888 200 PINE STREET SUITE 400 SAN FRANCISCO CA 94104 Rule 13d-1(c) Iliad Research & Trading, L.P. UT 440000.00 0.00 440000.00 0.00 440000.00 9.8 PN * Based on 4,497,108 shares outstanding as of December 10, 2025. Iliad Management, LLC DE 440000.00 0.00 440000.00 0.00 440000.00 9.8 OO * Based on 4,497,108 shares outstanding as of December 10, 2025. Fife Trading, Inc. IL 440000.00 0.00 440000.00 0.00 440000.00 9.8 OO * Based on 4,497,108 shares outstanding as of December 10, 2025. John M. Fife X1 440000.00 0.00 440000.00 0.00 440000.00 9.8 IN * Based on 4,497,108 shares outstanding as of December 10, 2025. Jaguar Health, Inc. 200 PINE STREET SUITE 400, SAN FRANCISCO, CALIFORNIA, 94104 This report is filed by Iliad Research and Trading, LP, Iliad Management, LLC, Fife Trading, Inc., and John M. Fife with respect to the shares of Common Stock, $0.0001 par value per share, of the Issuer that are directly beneficially owned by Iliad Research and Trading, LP and indirectly beneficially owned by the other reporting and filing persons. 300 East Randolph Street, Suite 40.150, Chicago, IL 60601 Iliad Research and Trading, LP is a Utah limited partnership. Iliad Management, LLC is a Delaware limited liability company. Fife Trading, Inc. is an Illinois corporation. John M. Fife is a United States citizen. Y 440,000 9.8% 440,000 0 440,000 0 Y N Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Iliad Research & Trading, L.P. John Fife 12/11/2025 Iliad Management, LLC John Fife 12/11/2025 Fife Trading, Inc. John Fife 12/11/2025 John M. Fife John Fife 12/11/2025