X0306 4 2019-02-22 0 0001461993 MELINTA THERAPEUTICS, INC. /NEW/ MLNT 0001410781 JOHNSON JOHN C/O MELINTA THERAPEUTICS, INC. 300 GEORGE STREET, SUITE 301 NEW HAVEN CT 06511 1 1 0 0 Chief Executive Officer Restricted Stock Units 0.00 2019-02-22 4 A 0 400000 0.00 A Common Stock 400000 400000 D The restricted stock units will vest in equal quarterly installments over the two year period following February 22, 2019, subject to Mr. Johnson's continued service with the Issuer through the applicable vesting date. All share numbers in this Form 4 reflect the 1-for-5 reverse stock split which became effective as of 5 p.m. February 21, 2019. /s/ John Johnson 2019-02-22