X0306 4 2018-10-26 0 0001461993 MELINTA THERAPEUTICS, INC. /NEW/ MLNT 0001410781 JOHNSON JOHN C/O MELINTA THERAPEUTICS, INC. 300 GEORGE STREET, SUITE 301 NEW HAVEN CT 06511 1 1 0 0 Interim CEO Stock Option (right to buy) 2.80 2018-10-26 4 A 0 150000 0.00 A 2028-10-26 Common Stock 150000 150000 D Restricted Stock Units 0.00 2018-10-26 4 A 0 50000 0.00 A Common Stock 50000 50000 D The award vests in equal monthly installments over a period of 12 months from October 18, 2018, subject to the Reporting Person continuing to provide services in any capacity (including, but not limited to, service as a member of the Board of Directors). The award vests in full and will be settled on October 18, 2019, subject to the Reporting Person continuing to provide services in any capacity (including, but not limited to, service as a member of the Board of Directors). /s/ Russ Causey, attorney in fact 2018-10-29