POWER OF ATTORNEY

        Know all by these presents, that the undersigned hereby constitutes and
appoints each of Paul Estrem, Susan Blum and Russ Causey, and each of them
acting alone, signing singly, the undersigned's true and lawful attorney-in-fact
to:  (1) execute for and on behalf of the undersigned, in the undersigned's
capacity as an officer, director and/or 10% or more stockholder of Melinta
Therapeutics, Inc. (the "Company"), Forms 3, 4 and 5, and Update Passphrase
Acknowledgement  (and any amendments thereto) in accordance with Section 16(a)
of the Securities Exchange Act of 1934, as amended (the "1934 Act"), and the
rules promulgated thereunder; (2) do and perform any and all acts for and on
behalf of the undersigned which may be necessary or desirable to complete and
execute any such Form 3, 4 and 5, and Update Passphrase Acknowledgement (and any
amendments thereto) and to file timely such form with the United States
Securities and Exchange Commission and any stock exchange or similar authority;
and (3) take any other action of any type whatsoever in connection with the
foregoing which in the opinion of such attorney-in-fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of the
undersigned pursuant to this Power of Attorney shall be in such form and shall
contain such terms and conditions as such attorney-in-fact may approve in such
attorney-in-fact's discretion.

        The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or such attorney-in- fact's substitute or substitutes, shall
lawfully do or cause to be done by virtue of this power of attorney and the
rights and powers herein granted.  The undersigned acknowledges that the
foregoing attorneys-in-fact, in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company assuming, any of the
undersigned's responsibilities to comply with Section 16 of the 1934 Act.

        This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4 and 5, and Update
Passphrase Acknowledgement with respect to the undersigned's holdings of and
transactions in securities issued by the Company, unless earlier revoked by the
undersigned, in a signed writing delivered to each of the foregoing attorneys-
in-fact.

        IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 30th day of May 2018.


                                        /s/ Daniel Wechsler
                                        ---------------------------------------
                                        Daniel Wechsler