<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001461990</cik>
        <entityName>NUVAIRA, INC.</entityName>
        <issuerAddress>
            <street1>3750 ANNAPOLIS LANE NORTH, Suite 105</street1>
            <city>PLYMOUTH</city>
            <stateOrCountry>MN</stateOrCountry>
            <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
            <zipCode>55447</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>763-450-2800</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>HOLAIRA, INC.</previousName>
            <previousName>Innovative Pulmonary Solutions, Inc.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dennis</firstName>
                <middleName>W.</middleName>
                <lastName>Wahr</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>A.</middleName>
                <lastName>Carusi</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Henry</firstName>
                <middleName>A.</middleName>
                <lastName>Plain</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Carolyn</firstName>
                <lastName>Ng</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jonathan</firstName>
                <lastName>Root</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alexander</firstName>
                <lastName>Schmitz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <lastName>Shen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tim</firstName>
                <lastName>Herbert</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3750 ANNAPOLIS LANE NORTH</street1>
                <street2>Suite 105</street2>
                <city>Plymouth</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55447</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2020-07-13</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>49999997</totalOfferingAmount>
            <totalAmountSold>17417640</totalAmountSold>
            <totalRemaining>32582357</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>44</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Excludes standard compensation for officers and directors.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>NUVAIRA, INC.</issuerName>
                <signatureName>/s/ Dennis W. Wahr</signatureName>
                <nameOfSigner>Dennis W. Wahr</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2020-07-28</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
