<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
<schemaVersion>X0202</schemaVersion>
<headerData>
<submissionType>SCHEDULE 13G</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001423686</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<securitiesClassTitle>Common Stock, par value $0.0001 per share</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>06/30/2026</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0001459839</issuerCik>
<issuerName>SI-BONE, Inc.</issuerName>
<issuerCusips>
<issuerCusipNumber>825704109</issuerCusipNumber>
</issuerCusips>
<issuerPrincipalExecutiveOfficeAddress>
<com:street1>471 El Camino Real, Suite 101</com:street1>
<com:city>Santa Clara</com:city>
<com:stateOrCountry>CA</com:stateOrCountry>
<com:zipCode>95050</com:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
</coverPageHeader>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Cadian Capital Management, LP</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>3347574</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>3347574</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3347574</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>7.5</classPercent>
<typeOfReportingPerson>IA</typeOfReportingPerson>
<typeOfReportingPerson>PN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Cadian Capital Management GP, LLC</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>3347574</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>3347574</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3347574</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>7.5</classPercent>
<typeOfReportingPerson>OO</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>ERIC BANNASCH</reportingPersonName>
<citizenshipOrOrganization>X1</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>3347574</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>3347574</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3347574</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>7.5</classPercent>
<typeOfReportingPerson>IN</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<items>
<item1>
<issuerName>SI-BONE, Inc.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>471 El Camino Real, Suite 101, Santa Clara, California, 95050</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>(i) Cadian Capital Management, LP, (ii) Cadian Capital Management GP, LLC, and (iii) Eric Bannasch (collectively, the "Reporting Persons")</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>For each of the Reporting Persons:  535 Madison Avenue, 36th Floor, New York, New York 10022</principalBusinessOfficeOrResidenceAddress>
<citizenship>(i) Cadian Capital Management, LP is a Delaware limited partnership, (ii) Cadian Capital Management GP, LLC is a Delaware limited liability company, and (iii) Eric Bannasch is a United States citizen.</citizenship>
</item2>
<item3>
<notApplicableFlag>N</notApplicableFlag>
<typeOfPersonFiling>IA</typeOfPersonFiling>
<typeOfPersonFiling>HC</typeOfPersonFiling>
</item3>
<item4>
<amountBeneficiallyOwned>As of June 30, 2026, each of the Reporting Persons may have been deemed to have beneficially owned 3,347,574 shares of Common Stock, par value $0.0001 per share ("Common Stock"), of SI-BONE, Inc. (the "Issuer").  All securities reported in this Schedule 13G were directly held by Cadian Master Fund L.P. and Cadian Opportunities Master Fund LP (collectively, the "Advisory Clients"), advisory clients of Cadian Capital Management, LP (the "Adviser").  Pursuant to Investment Management Agreements between the Advisory Clients and the Adviser, the Adviser exercises exclusive voting and investment power over securities directly held by the Advisory Clients.  Cadian Capital Management GP, LLC is the general partner of the Adviser.  Eric Bannasch is the sole managing member of Cadian Capital Management GP, LLC.</amountBeneficiallyOwned>
<classPercent>As of June 30, 2026, each of the Reporting Persons may have been deemed to have beneficially owned approximately 7.5% of the shares of Common Stock of the Issuer outstanding, based on 44,697,215 shares of Common Stock outstanding as of June 30, 2026, as disclosed in the Issuer's Form 10-Q filed with the Securities and Exchange Commission on August 4, 2026.</classPercent>
<numberOfSharesPersonHas>
<solePowerOrDirectToVote>As of June 30, 2026, each of the Reporting Persons may have been deemed to have had sole power to vote or to direct the vote of 0 shares of Voting Common Stock.</solePowerOrDirectToVote>
<sharedPowerOrDirectToVote>As of June 30, 2026, each of the Reporting Persons may have been deemed to have had shared power to vote or to direct the vote of 3,347,574 shares of Voting Common Stock.</sharedPowerOrDirectToVote>
<solePowerOrDirectToDispose>As of June 30, 2026, each of the Reporting Persons may have been deemed to have had sole power to dispose or to direct the disposition of 0 shares of Voting Common Stock.</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>As of June 30, 2026, each of the Reporting Persons may have been deemed to have had shared power to dispose or to direct the disposition of 3,347,574 shares of Voting Common Stock.</sharedPowerOrDirectToDispose>
</numberOfSharesPersonHas>
</item4>
<item5>
<notApplicableFlag>Y</notApplicableFlag>
</item5>
<item6>
<notApplicableFlag>N</notApplicableFlag>
<ownershipMoreThan5PercentOnBehalfOfAnotherPerson>All securities reported in this Schedule 13G were directly held by the Advisory Clients. Cadian Master Fund L.P. individually directly holds Common Stock representing more than 5% of the Issuer's Common Stock.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
</item6>
<item7>
<notApplicableFlag>N</notApplicableFlag>
<subsidiaryIdentificationAndClassification>The disclosure regarding the relationships among the Reporting Persons in Item 4 is incorporated by reference herein.</subsidiaryIdentificationAndClassification>
</item7>
<item8>
<notApplicableFlag>Y</notApplicableFlag>
</item8>
<item9>
<notApplicableFlag>Y</notApplicableFlag>
</item9>
<item10>
<notApplicableFlag>N</notApplicableFlag>
<certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
</item10>
</items>
<exhibitInfo>99.1   Joint Filing Agreement, dated as of August 14, 2026 by and among the Reporting Persons</exhibitInfo>
<signatureInformation>
<reportingPersonName>Cadian Capital Management, LP</reportingPersonName>
<signatureDetails>
<signature>/s/ Eric Bannasch</signature>
<title>Eric Bannasch/Managing Member, Cadian Capital Management GP, LLC, its General Partner</title>
<date>08/14/2026</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Cadian Capital Management GP, LLC</reportingPersonName>
<signatureDetails>
<signature>/s/ Eric Bannasch</signature>
<title>Eric Bannasch/Managing Member</title>
<date>08/14/2026</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>ERIC BANNASCH</reportingPersonName>
<signatureDetails>
<signature>/s/ Eric Bannasch</signature>
<title>Eric Bannasch/Self</title>
<date>08/14/2026</date>
</signatureDetails>
</signatureInformation>
</formData>

</edgarSubmission>
