X0306 4 2015-03-17 0 0001082038 DURECT CORP DRRX 0001459708 21 APRIL FUND LTD CITCO FUND SERVICES (CAYMAN ISLANDS) LTD REGATTA OFFICE PARK WEST BAY ROAD GRAND CAYMAN E9 KY1-1205 CAYMAN ISLANDS 0 0 1 0 0001637141 Arnhold & S. Bleichroeder Holdings, Inc. 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 0001459688 21 APRIL FUND LP FIRST EAGLE INVESTMENT MANAGEMENT, LLC 1345 AVENUE OF THE AMERICAS, 44TH FLOOR NEW YORK NY 10105 0 0 1 0 0001457518 First Eagle Value in Biotechnology Master Fund, Ltd. CITCO FUND SERVICES (CAYMAN ISLANDS) LTD REGATTA OFFICE PARK WEST BAY ROAD GRAND CAYMAN E9 KY1-1205 CAYMAN ISLANDS 0 0 1 0 Common Stock 2015-03-17 4 P 0 67200 1.59 A 13196397 D Common Stock 2015-09-29 4 P 0 885049 1.8 A 14081446 D Represents 9,579, 35,221 and 22,400 shares purchased by 21 April Fund, LP ("21 April LP"), 21 April Fund, Ltd. ("21 April Ltd."), and First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBM" and, together with 21 April LP and 21 April Ltd., the "Funds"), respectively. First Eagle Management, LLC ("FEIM") is general partner of 21 April LP, the registered investment adviser to the Funds and a subsidiary of Arnhold and S. Bleichroeder Holdings, Inc. ("ASBH"). ASBH disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its percuniary interest therein, and this report shall not be deemed an admission that ASBH is the Section 16 beneficial owner of any such securities. Represents 1,729,489, 6,379,964 and 5,086,944 shares held directly by 21 April LP, 21 April Ltd. and FEVIBM, respectively. ASBH disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that ASBH is the Section 16 beneficial owner of any such securities. Represents 206,806 and 678,243 shares purchased by 21 April LP and 21 April Ltd., respectively. ASBH disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that ASBH is the Section 16 beneficial owner of any such securities. Represents 1,936,295, 7,058,207 and 5,086,944 shares held directly by 21 April LP, 21 April Ltd. and FEVIBM, respectively. ASBH disclaims Section 16 beneficial ownership of the shares held directly by the Funds except to the extent, if any, of its pecuniary interest therein, and this report shall not be deemed an admission that ASBH is the Section 16 beneficial owner of any such securities. ARNOLD AND S. BLEICHROEDER HOLDINGS, INC., By: /s/ Michael M. Kellen, Co-President 2015-10-01 FIRST EAGLE INVESTMENT MANAGEMENT, LLC, as General Partner of 21 April LP and Investment Adviser of 21 April Ltd. and FEVIBM, By: /s/ Michael M. Kellen, Vice Chairman and Director 2015-10-01