X0306 4 2013-08-27 0 0001013238 ARADIGM CORP ARDM 0001325447 First Eagle Investment Management, LLC 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 0001457518 First Eagle Value in Biotechnology Master Fund, Ltd. 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 0001459708 21 APRIL FUND LTD 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 0001459688 21 APRIL FUND LP 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 0001506964 DEF Associates LP 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 0000754094 DEF Associates Ltd. 1345 AVENUE OF THE AMERICAS NEW YORK NY 10105 0 0 1 0 Common Stock, no par value (the "Common Stock") 2013-08-27 4 P 0 40322580 0.124 A 154326899 I See footnotes The shares of Common Stock to which this relates are held directly by First Eagle Value in Biotechnology Master Fund, Ltd., a Cayman Islands exempted company ("FEVIB"), 21 April Fund, Ltd., a Cayman Islands exempted company ("April LTD"), 21 April Fund, L.P., a Delaware limited partnership ("April LP"), DEF Associates, LP, a Delaware limited partnership ("DEF LP"), DEF Associates, Ltd., a British Virgin Islands corporation ("DEF LTD" and together with FEVIB, April LTD, April LP and DEF LP, the "Funds"), and certain managed accounts (collectively, the "Accounts"). The shares of Common Stock reported herein are indirectly beneficially owned by First Eagle Investment Management, LLC, a Delaware limited liability company and an investment adviser registered under the Investment Advisers Act of 1940 ("FEIM"), by virtue of its service as investment manager to the Funds and Accounts, which are under FEIM's management and control. Each of the reporting persons disclaims beneficial ownership of the securities to which this Form 4 relates for the purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of the reporting person's pecuniary interest in the securities. First Eagle Investment Management, LLC, By: /s/ Mark Goldstein, Senior Vice President 2013-08-29