X0303 4 2010-02-24 0 0001459450 Myriad Pharmaceuticals, Inc. MYRX 0001465780 Berry Barbara C/O MYRIAD PHARMACEUTICALS, INC. 305 CHIPETA WAY SALT LAKE CITY UT 84108 0 1 0 0 SVP, Human Resources Common Stock 2010-02-24 4 M 0 526 3.96 A 17284 D Employee Stock Option (Right to Buy) 3.96 2010-02-24 4 M 0 526 0 D 2010-06-20 Common Stock 526 0 D Includes 1,336 shares acquired under the Issuer's Employee Stock Purchase Plan on December 1, 2009. The option was issued in connection with the spin-off of the Issuer by Myriad Genetics, Inc. ("MGI") on 06/30/09, pursuant to which each outstanding MGI option was converted into an adjusted MGI option, exercisable for the same number of shares of common stock as the original MGI option, and a new Issuer option, exercisable for one-fourth of the number of shares of common stock as the original MGI option. An adjusted exercise price of each converted option was determined in accordance with Section 409A and Section 422 of the Internal Revenue Code of 1986. All other terms of the converted options remain the same however; the vesting and expiration is based on the optionholder's continuing employment with MGI or the Issuer, as applicable, following the spin-off. The original MGI option was granted on 06/20/00 (the "Date of Grant"). The option vested over a five-year period as to 20% of the shares on each anniversary of the Date of Grant. /s/ Ann Margaret Eames, Attorney-in-Fact 2010-02-26