X0306 4 2021-05-05 0 0001459417 2U, Inc. TWOU 0001013713 MAEDER PAUL A C/O 2U, INC. 7900 HARKINS ROAD LANHAM MD 20706 1 0 0 0 Common Stock 2021-05-05 4 A 0 6054 0.00 A 69215 D Common Stock 2021-05-05 4 A 0 1399 39.31 A 70614 D Common Stock 2021-05-05 4 A 0 1755 39.31 A 72369 D Common Stock 2021-05-05 4 A 0 317 39.31 A 72686 D Common Stock 39946 I By Altaheide LLC The security represents restricted stock units granted to the reporting person. Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer. The shares underlying this restricted stock unit award will vest in full on April 1, 2022, subject to the reporting person's continued service as a director of the issuer as of that date. The restricted stock units were issued to the reporting person in lieu of annual director retainer fees of $55,000. The restricted stock units were issued to the reporting person in lieu of annual chair retainer fees of $69,000. The restricted stock units were issued to the reporting person in lieu of annual committee member retainer fees of $12,500. These shares are held by Altaheide LLC, the sole members of which are certain trusts for the benefit of the reporting person's children. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. /s/ Matthew J. Norden, attorney-in-fact 2021-05-07