X0306 4/A 2015-09-15 2015-09-17 0 0001374690 ZAFGEN, INC. ZFGN 0001456750 KIM DENNIS D C/O ZAFGEN, INC. 175 PORTLAND STREET, 4TH FLOOR BOSTON MA 02114 0 1 0 0 Chief Medical Officer Common Stock 2015-09-15 4 S 0 30265 40.00 D 0 D Common Stock 2015-09-17 4 S 0 9142 40.00 D 0 D This amendment is being filed to disclose that the sale of these shares reported in the original Form 4 by the Reporting Person was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 28, 2015 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. /s/ Laurie Burlingame (Attorney-In-Fact) 2015-10-20