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<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-04-29</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001544227</issuerCik>
        <issuerName>Tempest Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>TPST</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001687880</rptOwnerCik>
            <rptOwnerName>Versant Venture Capital VI, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isTenPercentOwner>1</isTenPercentOwner>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001777654</rptOwnerCik>
            <rptOwnerName>Versant Ventures VI GP, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001777652</rptOwnerCik>
            <rptOwnerName>Versant Ventures VI GP-GP, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001832235</rptOwnerCik>
            <rptOwnerName>Versant Vantage II, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001839790</rptOwnerCik>
            <rptOwnerName>Versant Vantage II GP, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isDirector>0</isDirector>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001839789</rptOwnerCik>
            <rptOwnerName>Versant Vantage II GP-GP, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001456589</rptOwnerCik>
            <rptOwnerName>Versant Ventures IV, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001456590</rptOwnerCik>
            <rptOwnerName>Versant Venture Capital IV, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001456591</rptOwnerCik>
            <rptOwnerName>Versant Side Fund IV, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
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    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>997940</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1171094</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7377</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2118644</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares are held of record by Versant Venture Capital VI, L.P. (&quot;VVC VI&quot;). Versant Ventures VI GP, L.P. (&quot;VV VI GP&quot;) is the general partner of VVC VI, and Versant Ventures VI GP-GP, LLC (&quot;VV VI GP-GP&quot;) is the general partner of VV VI GP. Thomas Woiwode, a member of the Issuer's board of directors, is a managing director of VV VI GP-GP and may be deemed to share voting and dispositive power over the shares held by VVC VI. Each of VV VI GP-GP, VV VI GP and Thomas Woiwode disclaim beneficial ownership of such securities, except to the extent of their respective pecuniary interests therein. Thomas Woiwode is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F2">These shares are held of record by Versant Venture Capital IV, L.P. (&quot;VVC IV&quot;). Versant Ventures IV, LLC (&quot;VV IV&quot;) is the general partner of VVC IV. Thomas Woiwode, a member of the Issuer's board of directors, is a managing director of VV IV and may be deemed to share voting and dispositive power over the shares held by VVC IV. Each of VV IV and Thomas Woiwode disclaim beneficial ownership of such securities, except to the extent of their respective pecuniary interests therein. Thomas Woiwode is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F3">These shares are held of record by Versant Side Fund IV, L.P. (&quot;VSF IV&quot;). VV IV is the general partner of VSF IV. Thomas Woiwode, a member of the Issuer's board of directors, is a managing director of VV IV and may be deemed to share voting and dispositive power over the shares held by VSF IV. Each of VV IV and Thomas Woiwode disclaim beneficial ownership of such securities, except to the extent of their respective pecuniary interests therein. Thomas Woiwode is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F4">These shares are held of record by Versant Vantage II, L.P. (&quot;Vantage II&quot;) and the acquisition of which was reported on a Form 3 filed by Vantage II and its general partner entities on the date hereof. Versant Vantage II GP, L.P. (&quot;Vantage II GP&quot;) is the general partner of Vantage II, and Versant Vantage II GP-GP, LLC (&quot;Vantage II GP-GP&quot;) is the general partner of Vantage II GP. Thomas Woiwode, a member of the Issuer's board of directors, is a managing director of Vantage II GP-GP and may be deemed to share voting and dispositive power over the shares held by Vantage II. Each of Vantage II GP-GP, Vantage II GP and Thomas Woiwode disclaim beneficial ownership of such securities, except to the extent of their respective pecuniary interests therein. Thomas Woiwode is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Versant Venture Capital VI, L.P. By: Versant Ventures VI GP, L.P. Its: General Partner By: Versant Ventures VI GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Ventures VI GP, L.P. By: Versant Ventures VI GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Ventures VI GP-GP, LLC By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Vantage II, L.P. By: Versant Vantage II GP, L.P. Its: General Partner By: Versant Vantage II GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Vantage II GP, L.P. By: Versant Vantage II GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Vantage II GP-GP, LLC By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Ventures IV, LLC By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Venture Capital IV, L.P. By: Versant Ventures IV, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Side Fund IV, L.P. By: Versant Ventures IV, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2022-05-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
