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Stock Incentive Plans - Plan information and assumptions (Details)
$ / shares in Units, $ in Thousands
6 Months Ended 12 Months Ended
Jun. 21, 2016
shares
May 24, 2016
Jun. 30, 2016
USD ($)
$ / shares
shares
Jun. 30, 2015
$ / shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock reserved for future issuance     3,046,784   12,826,886
2008 Plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of shares authorized for grants     2,213,412    
Common stock reserved for future issuance     10,163    
2016 Plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of shares authorized for grants     1,210,256    
Common stock reserved for future issuance     819,451    
ESPP          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock reserved for future issuance 173,076        
Maximum percentage of shares available may increase each year 0.01        
Stock incentive awards          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock reserved for future issuance     819,451   100,034
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]          
Risk-free interest rate     1.39% 1.70%  
Weighted-average fair value of stock options | $ / shares     $ 9.84   $ 5.03
Aggregate intrinsic value | $     $ 900   $ 300
Unrecognized compensation expense related to unvested employee stock options | $     $ 5,700   $ 2,300
Weighted average period for recognizing, unrecognized compensation expense     3 years   3 years 1 month 6 days
Stock incentive awards | 2008 Plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting period     4 years    
Expiration period     10 years    
Forfeitures rate     10.00%    
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]          
Expected life     6 years 18 days 6 years 7 days  
Expected volatility     96.10% 93.50%  
Weighted-average fair value of common stock | $ / shares     $ 12.60 $ 9.22  
Aggregate intrinsic value | $     $ 11,134    
Stock incentive awards | 2008 Plan | Minimum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Employees holding voting rights of all classes of stock (as a percent)     10.00%    
Exercise price of options on common stock (as a percent)     110.00%    
Stock incentive awards | 2008 Plan | Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Employees holding voting rights of all classes of stock (as a percent)     10.00%    
Exercise price of options on common stock (as a percent)     100.00%    
Stock incentive awards | 2016 Plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting period   4 years      
Expiration period   10 years      
Stock incentive awards | 2016 Plan | Minimum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Employees holding voting rights of all classes of stock (as a percent)   10.00%      
Exercise price of options on common stock (as a percent)   110.00%      
Stock incentive awards | 2016 Plan | Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Employees holding voting rights of all classes of stock (as a percent)   10.00%      
Exercise price of options on common stock (as a percent)   100.00%      
Non-employee stock options          
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]          
Risk-free interest rate     1.46% 1.50%  
Expected life     9 years 8 months 12 days 6 years 9 months 18 days  
Expected volatility     90.37% 97.07%  
Non‑employee stock‑based compensation expense | $     $ 100   $ 400
Unrecognized compensation expense related to unvested non-employee stock options | $     900   $ 100
Non-employee stock options | 2008 Plan          
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]          
Aggregate intrinsic value | $     $ 4,080