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Nature of the Business and Basis of Presentation - Liquidity (Details) - USD ($)
$ in Thousands
Mar. 31, 2020
Dec. 31, 2019
Mar. 31, 2019
Dec. 31, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]        
Accumulated deficit $ 355,373 $ 335,753 $ 335,800  
Cash and Cash Equivalents [Line Items]        
Cash, cash equivalents, and restricted cash 74,264 $ 91,551 $ 32,452 $ 37,682
Restricted cash and cash equivalents 1,700      
Russian subsidiary | Unrestricted cash        
Cash and Cash Equivalents [Line Items]        
Cash, cash equivalents, and restricted cash $ 300