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Nature of the Business and Basis of Presentation - Liquidity (Details) - USD ($)
$ in Thousands
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]        
Accumulated deficit $ 335,753 $ 280,403    
Cash and Cash Equivalents [Line Items]        
Cash, cash equivalents, and restricted cash 91,551 $ 37,682 $ 71,027 $ 59,050
Restricted cash and cash equivalents 1,700      
Russian subsidiary | Unrestricted cash        
Cash and Cash Equivalents [Line Items]        
Cash, cash equivalents, and restricted cash $ 400