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Schedule of Share-based Compensation, Stock Options, Activity (Details) - Equity Option [Member] - 2018 Equity Incentive Plan [Member] - $ / shares
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Shares, Outstanding, Beginning Balance 3,201,666 2,190,892
Weighted Average Exercise Price, Outstanding Beginning Balance $ 1.80 $ 2.25
Shares, Granted 109,164
Weighted Average Exercise Price, Cancelled or expired $ 0.65
Shares, Cancelled or expired (301,983) (125)
Weighted Average Exercise Price, Cancelled or expired $ 2.73 $ 372.00
Shares, Outstanding, Ending Balance 3,008,847 2,190,767
Weighted Average Exercise Price, Outstanding Ending Balance $ 1.66 $ 2.23
Weighted Average Remaining Contractual Term (Years) Outstanding 8 years 6 months 9 years 3 months 18 days
Shares, Exercisable, Ending Balance 648,849 122,614
Weighted Average Exercise Price, Exercisable Ending Balance $ 2.68 $ 14.38
Weighted Average Remaining Contractual Term (Years) Exercisable 7 years 6 months 7 years 7 months 6 days