X0306 4 2022-06-03 0000004962 AMERICAN EXPRESS CO AXP 0001452645 Leonsis Theodore C/O AMERICAN EXPRESS COMPANY 200 VESEY STREET NEW YORK NY 10285-5001 1 Common Stock 2022-06-03 4 S 0 4005 166.6305 D 0 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $166.73 to $166.53. The reporting person undertakes to provide to American Express Company, any security holder of American Express Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within this range. /s/ Kristina V. Fink, attorney-in-fact 2022-06-06